Development of multicellular organisms from a single cell is arguably one of the most fascinating phenomena in biology. Mechanistic understanding of such a complex process is an important scientific challenge. Our single cell work aligns with the development of a systems perspective framework to comprehend how individual cellular states emerge and collectively result in a homeostatic multicellular organism.
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Brooks, Aaron N., David J. Reiss, Antoine Allard, Wei-Ju Wu, Diego M. Salvanha, Christopher L. Plaisier, Sriram Chandrasekaran, Min Pan, Amardeep Kaur, and Nitin S. Baliga. “A System-Level Model for the Microbial Regulatory Genome.” Molecular Systems Biology 10 (2014): 740. Cite