Most influential publications in high-throughput screening (Gaggle)

Gaggle manuscript ranked in the top 100 (#49) "Most influential publications in high-throughput screening" in 2006

These articles represent the most influential publications in the high-throughput screening field for the year 2006. Publications were scored based upon the number of visitors to our portal who read the particular article. This popularity score was then scaled by a citation score calculated from the citation history of the journal and the principal investigator. Since these articles are too new to have amassed a reasonable citation history, we use our novel prediction technology to arrive at an estimated citation score. We use this scoring technique to identify the most important high-throughput screening publications every day at our high-throughput screening portal. Visit the portal every day to stay up to date with the latest research in the field.

  1. Björklund et al. (2006) Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature
  2. Sun et al. (2006) Management of singlet and triplet excitons for efficient white organic light-emitting devices. Nature
  3. Zhao et al. (2006) Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet
  4. Corma et al. (2006) High-throughput synthesis and catalytic properties of a molecular sieve with 18- and 10-member rings. Nature
  5. Malo et al. (2006) Statistical practice in high-throughput screening data analysis. Nat Biotechnol
  6. Wilhelm et al. (2006) Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov
  7. Lang et al. (2006) Cellular imaging in drug discovery. Nat Rev Drug Discov
  8. Titulaer et al. (2006) A database application for pre-processing, storage and comparison of mass spectra derived from patients and controls. BMC Bioinformatics
  9. Junker et al. (2006) VANTED: A system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics
  10. Hahne et al. (2006) Statistical methods and software for the analysis of high throughput reverse genetic assays using flow cytometry readouts. Genome Biol
  11. Narayanaswamy et al. (2006) Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes. Genome Biol
  12. Love et al. (2006) A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol
  13. Elshal et al. (2006) Multiplex bead array assays: Performance evaluation and comparison of sensitivity to ELISA. Methods
  14. Pritsker et al. (2006) Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc Natl Acad Sci U S A
  15. Sergeeva et al. (2006) Display technologies: Application for the discovery of drug and gene delivery agents. Adv Drug Deliv Rev
  16. Radhakrishnan et al. (2006) A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity. Cancer Res
  17. Tobler et al. (2005) The SNPlex Genotyping System: A Flexible and Scalable Platform for SNP Genotyping. J Biomol Tech
  18. Cagney et al. (2006) Functional genomics of the yeast DNA-damage response. Genome Biol
  19. Collins et al. (2006) A Strategy for Extracting and Analyzing Large-Scale Quantitative Epistatic Interaction Data. Genome Biol
  20. Cooks et al. (2006) Detection Technologies. Ambient mass spectrometry. Science
  21. Shi et al. (2006) Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences. Proc Natl Acad Sci U S A
  22. Mustata et al. (2006) Approaches to oral drug delivery for challenging molecules. Crit Rev Ther Drug Carrier Syst
  23. Barley-Maloney et al. (2006) Quality assessment of commercial small interfering RNA and DNA: Monoclonal antibodies and a high-throughput chemiluminescence assay. Anal Biochem
  24. Li et al. (2006) Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc Natl Acad Sci U S A
  25. Jensen et al. (2006) Literature mining for the biologist: from information retrieval to biological discovery. Nat Rev Genet
  26. Jin et al. (2006) qPCR-DAMS: a Database Tool to Analyze, Manage, and Store Both Relative and Absolute Quantitative Real-Time PCR data. Physiol Genomics
  27. Jongsma et al. (2006) Self-assembling protein arrays on DNA chips by auto-labeling fusion proteins with a single DNA address. Proteomics
  28. Clark et al. (N/A) Optoinjection for efficient targeted delivery of a broad range of compounds and macromolecules into diverse cell types. J Biomed Opt
  29. Leveau et al. (2006) Genomic flank-sequencing of plasposon insertion sites for rapid identification of functional genes. J Microbiol Methods
  30. Teufel et al. (2006) Current bioinformatics tools in genomic biomedical research (Review). Int J Mol Med
  31. Matsumura et al. (2006) SuperSAGE array: the direct use of 26-base-pair transcript tags in oligonucleotide arrays. Nat Methods
  32. Zamyatnin et al. (2006) Assessment of the integral membrane protein topology in living cells. Plant J
  33. Keppetipola et al. (2006) From Gene to HSQC in under Five Hours: High-Throughput NMR Proteomics. J Am Chem Soc
  34. Karimi et al. (2006) LUMA (LUminometric Methylation Assay)-A high throughput method to the analysis of genomic DNA methylation. Exp Cell Res
  35. Eastman et al. (2006) Qdot Nanobarcodes for Multiplexed Gene Expression Analysis. Nano Lett
  36. Engle et al. (2006) Using high-throughput SNP technologies to study cancer. Oncogene
  37. Inglese et al. (2006) Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A
  38. Yamamoto et al. (2006) A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. Anal Biochem
  39. Gipson et al. (2006) Weighted least-squares deconvolution method for discovery of group differences between complex biofluid (1)H NMR spectra. J Magn Reson
  40. Radhakrishnan et al. (2006) Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box m1. Cancer Res
  41. Ericsson et al. (2006) Thermofluor-based high-throughput stability optimization of proteins for structural studies. Anal Biochem
  42. Kawanishi et al. (2006) High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers. Cancer Sci
  43. Brown et al. (2006) Advances in molecular diagnostics for avian influenza. Dev Biol (Basel)
  44. Dorfman et al. (2006) Highly Sensitive Biomolecular Fluorescence Detection Using Nanoscale ZnO Platforms. Langmuir
  45. Demichelis et al. (2006) TMABoost: an integrated system for comprehensive management of tissue microarray data. IEEE Trans Inf Technol Biomed
  46. Jain et al. (2006) First LC-MS/MS electrospray ionization validated method for the quantification of perindopril and its metabolite perindoprilat in human plasma and its application to bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci
  47. Deisingh et al. (2006) Aptamer-based biosensors: biomedical applications. Handb Exp Pharmacol
  48. B et al. (2006) Laboratory Information Management Software for Genotyping Workflows: applications in high throughput crop genotyping. BMC Bioinformatics
  49. Shannon et al. (2006) Gaggle: An open-source software system for integrating bioinformatics software and data sources. BMC Bioinformatics
  50. Ma et al. (2006) Regularized binormal ROC method in disease classification using microarray data. BMC Bioinformatics
  51. Chagoyen et al. (2006) Discovering semantic features in the literature: a foundation for building functional associations. BMC Bioinformatics
  52. Jonsson et al. (2006) Cluster analysis of networks generated through homology: automatic identification of important protein communities involved in cancer metastasis. BMC Bioinformatics
  53. Nirogi et al. (2006) High-throughput quantification of perindopril in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study. Rapid Commun Mass Spectrom
  54. Szabadka et al. (2006) High throughput processing of the structural information in the protein data bank. J Mol Graph Model
  55. Al Kuraya et al. (2006) High throughput tissue microarray analysis of FHIT expression in diffuse large cell B-cell lymphoma from Saudi Arabia. Mod Pathol
  56. Meijer et al. (2006) Isolation of Human Antibody Repertoires with Preservation of the Natural Heavy and Light Chain Pairing. J Mol Biol
  57. Bibikova et al. (2006) High-throughput DNA methylation profiling using universal bead arrays. Genome Res
  58. Ho et al. (2006) Linking DNA-binding proteins to their recognition sequences by using protein microarrays. Proc Natl Acad Sci U S A
  59. Kolker et al. (2006) Protein identification and expression analysis using mass spectrometry. Trends Microbiol
  60. Murphey et al. (2006) Small molecule screening in the zebrafish. Methods
  61. Tao et al. (2006) Protein chip fabrication by capture of nascent polypeptides. Nat Biotechnol
  62. Trosset et al. (2006) Inhibition of protein-protein interactions: The discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins
  63. Nadal et al. (2006) A new PCR-CGE (size and color) method for simultaneous detection of genetically modified maize events. Electrophoresis
  64. Kim et al. (2006) Genome-Wide Analysis of Protein-DNA Interactions. Annu Rev Genomics Hum Genet
  65. Potts et al. (2005) Challenges of target/compound data integration from disease to chemistry: a case study of dihydrofolate reductase inhibitors. Curr Drug Discov Technol
  66. Krutzik et al. (2006) Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat Methods
  67. Wille et al. (2006) Low-order conditional independence graphs for inferring genetic networks. Stat Appl Genet Mol Biol
  68. Zhang et al. (2006) Carbohydrate-Protein Interactions by "Clicked" Carbohydrate Self-Assembled Monolayers. Anal Chem
  69. Fruhwirth et al. (2006) The alphaPROX assay: fluorescence screening of the inhibitory effects of hydrophilic antioxidants on protein oxidation. Anal Bioanal Chem
  70. Mantovani et al. (2006) A high throughput method for genome-wide analysis of retroviral integration. Nucleic Acids Res
  71. Lambeng et al. (2006) Arylsulfonamides as a new class of cannabinoid CB(1) receptor ligands: Identification of a lead and initial SAR studies. Bioorg Med Chem Lett
  72. Hofvind et al. (2006) Use of hormone therapy and risk of breast cancer detected at screening and between mammographic screens. Int J Cancer
  73. Ng et al. (2006) Resources for integrative systems biology: from data through databases to networks and dynamic system models. Brief Bioinform
  74. Schmitt et al. (2006) Bead-based multiplex genotyping of human papillomaviruses. J Clin Microbiol
  75. Khademhosseini et al. (2006) Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A
  76. Lu et al. (2006) A high-throughput screen for genes from castor that boost hydroxy fatty acid accumulation in seed oils of transgenic Arabidopsis. Plant J
  77. Kartalov et al. (2006) High-throughput multi-antigen microfluidic fluorescence immunoassays. Biotechniques
  78. Jothi et al. (2006) Co-evolutionary Analysis of Domains in Interacting Proteins Reveals Insights into Domain-Domain Interactions Mediating Protein-Protein Interactions. J Mol Biol
  79. Au et al. (2006) Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis. Acta Crystallogr D Biol Crystallogr
  80. Yaoi et al. (2006) SH2 domain-based high-throughput assays for profiling downstream molecules in receptor tyrosine kinase pathways. Mol Cell Proteomics
  81. Adiga et al. (2006) Development of high-throughput, polarization-maintaining, near-field probes. Appl Opt
  82. Hashimoto et al. (2006) Arabidopsis HT1 kinase controls stomatal movements in response to CO(2). Nat Cell Biol
  83. Braña et al. (2006) Anticancer drug discovery and pharmaceutical chemistry: a history. Clin Transl Oncol
  84. Jennewein et al. (2006) Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase. Biotechnol J
  85. White et al. (2005) EXUBERA(R): Pharmaceutical Development of a Novel Product for Pulmonary Delivery of Insulin. Diabetes Technol Ther
  86. Bonsor et al. (2006) Ligation independent cloning (LIC) as a rapid route to families of recombinant biocatalysts from sequenced prokaryotic genomes. Org Biomol Chem
  87. Cheng et al. (2006) A high-throughput urinalysis of abused drugs based on a SPE-LC-MS/MS method coupled with an in-house developed post-analysis data treatment system. Forensic Sci Int
  88. Escher et al. (2006) Passive sampling of herbicides combined with effect analysis in algae using a novel high-throughput phytotoxicity assay (Maxi-Imaging-PAM). J Environ Monit
  89. Elias et al. (2006) Confirmation of the expression of a large set of conserved hypothetical proteins in Shewanella oneidensis MR-1. J Microbiol Methods
  90. Berzsenyi et al. (2006) Genomics of hepatitis B and C infections: diagnostic and therapeutic applications of microarray profiling. Antivir Ther
  91. Casimiro et al. (2006) Identification of pathogenesis-related ESTs in the crucifer downy mildew oomycete Hyaloperonospora parasitica by high-throughput differential display analysis of distinct phenotypic interactions with Brassica oleracea. J Microbiol Methods
  92. Lehtinen et al. (2006) Real-time monitoring of antimicrobial activity with the multiparameter microplate assay. J Microbiol Methods
  93. Pepperkok et al. (2006) High-throughput fluorescence microscopy for systems biology. Nat Rev Mol Cell Biol
  94. Kotchoni et al. (2006) The reactive oxygen species network pathways:an essential prerequisite for perception of pathogen attack and the acquired disease resistance in plants. J Biosci
  95. Hemby et al. (2006) Chapter 9 Assessment of genome and proteome profiles in cocaine abuse. Prog Brain Res
  96. Büttelmann et al. (2006) Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett
  97. Harper et al. (2006) Methods for mining HTS data. Drug Discov Today
  98. Heydorn et al. (2006) Protein Translocation Assays: Key Tools for Accessing New Biological Information with High-Throughput Microscopy. Methods Enzymol
  99. Giancola et al. (2006) Utilization of the three high-throughput SNP genotyping methods, the GOOD assay, Amplifluor and TaqMan, in diploid and polyploid plants. Theor Appl Genet
  100. Lohkamp et al. (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. J Struct Biol

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