Most influential publications in high-throughput screening (Gaggle)

Gaggle manuscript ranked in the top 100 (#49) "Most influential publications in high-throughput screening" in 2006

These articles represent the most influential publications in the high-throughput screening field for the year 2006. Publications were scored based upon the number of visitors to our portal who read the particular article. This popularity score was then scaled by a citation score calculated from the citation history of the journal and the principal investigator. Since these articles are too new to have amassed a reasonable citation history, we use our novel prediction technology to arrive at an estimated citation score. We use this scoring technique to identify the most important high-throughput screening publications every day at our high-throughput screening portal. Visit the portal every day to stay up to date with the latest research in the field.

Björklund et al. (2006) Identification of pathways regulating cell size and cell-cycle progression by RNAi. Nature
Sun et al. (2006) Management of singlet and triplet excitons for efficient white organic light-emitting devices. Nature
Zhao et al. (2006) Circular chromosome conformation capture (4C) uncovers extensive networks of epigenetically regulated intra- and interchromosomal interactions. Nat Genet
Corma et al. (2006) High-throughput synthesis and catalytic properties of a molecular sieve with 18- and 10-member rings. Nature
Malo et al. (2006) Statistical practice in high-throughput screening data analysis. Nat Biotechnol
Wilhelm et al. (2006) Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov
Lang et al. (2006) Cellular imaging in drug discovery. Nat Rev Drug Discov
Titulaer et al. (2006) A database application for pre-processing, storage and comparison of mass spectra derived from patients and controls. BMC Bioinformatics
Junker et al. (2006) VANTED: A system for advanced data analysis and visualization in the context of biological networks. BMC Bioinformatics
Hahne et al. (2006) Statistical methods and software for the analysis of high throughput reverse genetic assays using flow cytometry readouts. Genome Biol
Narayanaswamy et al. (2006) Systematic profiling of cellular phenotypes with spotted cell microarrays reveals mating-pheromone response genes. Genome Biol
Love et al. (2006) A microengraving method for rapid selection of single cells producing antigen-specific antibodies. Nat Biotechnol
Elshal et al. (2006) Multiplex bead array assays: Performance evaluation and comparison of sensitivity to ELISA. Methods
Pritsker et al. (2006) Genomewide gain-of-function genetic screen identifies functionally active genes in mouse embryonic stem cells. Proc Natl Acad Sci U S A
Sergeeva et al. (2006) Display technologies: Application for the discovery of drug and gene delivery agents. Adv Drug Deliv Rev
Radhakrishnan et al. (2006) A novel transcriptional inhibitor induces apoptosis in tumor cells and exhibits antiangiogenic activity. Cancer Res
Tobler et al. (2005) The SNPlex Genotyping System: A Flexible and Scalable Platform for SNP Genotyping. J Biomol Tech
Cagney et al. (2006) Functional genomics of the yeast DNA-damage response. Genome Biol
Collins et al. (2006) A Strategy for Extracting and Analyzing Large-Scale Quantitative Epistatic Interaction Data. Genome Biol
Cooks et al. (2006) Detection Technologies. Ambient mass spectrometry. Science
Shi et al. (2006) Free-energy distribution of binary protein-protein binding suggests cross-species interactome differences. Proc Natl Acad Sci U S A
Mustata et al. (2006) Approaches to oral drug delivery for challenging molecules. Crit Rev Ther Drug Carrier Syst
Barley-Maloney et al. (2006) Quality assessment of commercial small interfering RNA and DNA: Monoclonal antibodies and a high-throughput chemiluminescence assay. Anal Biochem
Li et al. (2006) Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc Natl Acad Sci U S A
Jensen et al. (2006) Literature mining for the biologist: from information retrieval to biological discovery. Nat Rev Genet
Jin et al. (2006) qPCR-DAMS: a Database Tool to Analyze, Manage, and Store Both Relative and Absolute Quantitative Real-Time PCR data. Physiol Genomics
Jongsma et al. (2006) Self-assembling protein arrays on DNA chips by auto-labeling fusion proteins with a single DNA address. Proteomics
Clark et al. (N/A) Optoinjection for efficient targeted delivery of a broad range of compounds and macromolecules into diverse cell types. J Biomed Opt
Leveau et al. (2006) Genomic flank-sequencing of plasposon insertion sites for rapid identification of functional genes. J Microbiol Methods
Teufel et al. (2006) Current bioinformatics tools in genomic biomedical research (Review). Int J Mol Med
Matsumura et al. (2006) SuperSAGE array: the direct use of 26-base-pair transcript tags in oligonucleotide arrays. Nat Methods
Zamyatnin et al. (2006) Assessment of the integral membrane protein topology in living cells. Plant J
Keppetipola et al. (2006) From Gene to HSQC in under Five Hours: High-Throughput NMR Proteomics. J Am Chem Soc
Karimi et al. (2006) LUMA (LUminometric Methylation Assay)-A high throughput method to the analysis of genomic DNA methylation. Exp Cell Res
Eastman et al. (2006) Qdot Nanobarcodes for Multiplexed Gene Expression Analysis. Nano Lett
Engle et al. (2006) Using high-throughput SNP technologies to study cancer. Oncogene
Inglese et al. (2006) Quantitative high-throughput screening: A titration-based approach that efficiently identifies biological activities in large chemical libraries. Proc Natl Acad Sci U S A
Yamamoto et al. (2006) A nonradioisotope, enzymatic assay for 2-deoxyglucose uptake in L6 skeletal muscle cells cultured in a 96-well microplate. Anal Biochem
Gipson et al. (2006) Weighted least-squares deconvolution method for discovery of group differences between complex biofluid (1)H NMR spectra. J Magn Reson
Radhakrishnan et al. (2006) Identification of a chemical inhibitor of the oncogenic transcription factor forkhead box m1. Cancer Res
Ericsson et al. (2006) Thermofluor-based high-throughput stability optimization of proteins for structural studies. Anal Biochem
Kawanishi et al. (2006) High throughput comparative genomic hybridization array analysis of multifocal urothelial cancers. Cancer Sci
Brown et al. (2006) Advances in molecular diagnostics for avian influenza. Dev Biol (Basel)
Dorfman et al. (2006) Highly Sensitive Biomolecular Fluorescence Detection Using Nanoscale ZnO Platforms. Langmuir
Demichelis et al. (2006) TMABoost: an integrated system for comprehensive management of tissue microarray data. IEEE Trans Inf Technol Biomed
Jain et al. (2006) First LC-MS/MS electrospray ionization validated method for the quantification of perindopril and its metabolite perindoprilat in human plasma and its application to bioequivalence study. J Chromatogr B Analyt Technol Biomed Life Sci
Deisingh et al. (2006) Aptamer-based biosensors: biomedical applications. Handb Exp Pharmacol
B et al. (2006) Laboratory Information Management Software for Genotyping Workflows: applications in high throughput crop genotyping. BMC Bioinformatics
Shannon et al. (2006) Gaggle: An open-source software system for integrating bioinformatics software and data sources. BMC Bioinformatics
Ma et al. (2006) Regularized binormal ROC method in disease classification using microarray data. BMC Bioinformatics
Chagoyen et al. (2006) Discovering semantic features in the literature: a foundation for building functional associations. BMC Bioinformatics
Jonsson et al. (2006) Cluster analysis of networks generated through homology: automatic identification of important protein communities involved in cancer metastasis. BMC Bioinformatics
Nirogi et al. (2006) High-throughput quantification of perindopril in human plasma by liquid chromatography/tandem mass spectrometry: application to a bioequivalence study. Rapid Commun Mass Spectrom
Szabadka et al. (2006) High throughput processing of the structural information in the protein data bank. J Mol Graph Model
Al Kuraya et al. (2006) High throughput tissue microarray analysis of FHIT expression in diffuse large cell B-cell lymphoma from Saudi Arabia. Mod Pathol
Meijer et al. (2006) Isolation of Human Antibody Repertoires with Preservation of the Natural Heavy and Light Chain Pairing. J Mol Biol
Bibikova et al. (2006) High-throughput DNA methylation profiling using universal bead arrays. Genome Res
Ho et al. (2006) Linking DNA-binding proteins to their recognition sequences by using protein microarrays. Proc Natl Acad Sci U S A
Kolker et al. (2006) Protein identification and expression analysis using mass spectrometry. Trends Microbiol
Murphey et al. (2006) Small molecule screening in the zebrafish. Methods
Tao et al. (2006) Protein chip fabrication by capture of nascent polypeptides. Nat Biotechnol
Trosset et al. (2006) Inhibition of protein-protein interactions: The discovery of druglike beta-catenin inhibitors by combining virtual and biophysical screening. Proteins
Nadal et al. (2006) A new PCR-CGE (size and color) method for simultaneous detection of genetically modified maize events. Electrophoresis
Kim et al. (2006) Genome-Wide Analysis of Protein-DNA Interactions. Annu Rev Genomics Hum Genet
Potts et al. (2005) Challenges of target/compound data integration from disease to chemistry: a case study of dihydrofolate reductase inhibitors. Curr Drug Discov Technol
Krutzik et al. (2006) Fluorescent cell barcoding in flow cytometry allows high-throughput drug screening and signaling profiling. Nat Methods
Wille et al. (2006) Low-order conditional independence graphs for inferring genetic networks. Stat Appl Genet Mol Biol
Zhang et al. (2006) Carbohydrate-Protein Interactions by "Clicked" Carbohydrate Self-Assembled Monolayers. Anal Chem
Fruhwirth et al. (2006) The alphaPROX assay: fluorescence screening of the inhibitory effects of hydrophilic antioxidants on protein oxidation. Anal Bioanal Chem
Mantovani et al. (2006) A high throughput method for genome-wide analysis of retroviral integration. Nucleic Acids Res
Lambeng et al. (2006) Arylsulfonamides as a new class of cannabinoid CB(1) receptor ligands: Identification of a lead and initial SAR studies. Bioorg Med Chem Lett
Hofvind et al. (2006) Use of hormone therapy and risk of breast cancer detected at screening and between mammographic screens. Int J Cancer
Ng et al. (2006) Resources for integrative systems biology: from data through databases to networks and dynamic system models. Brief Bioinform
Schmitt et al. (2006) Bead-based multiplex genotyping of human papillomaviruses. J Clin Microbiol
Khademhosseini et al. (2006) Microscale technologies for tissue engineering and biology. Proc Natl Acad Sci U S A
Lu et al. (2006) A high-throughput screen for genes from castor that boost hydroxy fatty acid accumulation in seed oils of transgenic Arabidopsis. Plant J
Kartalov et al. (2006) High-throughput multi-antigen microfluidic fluorescence immunoassays. Biotechniques
Jothi et al. (2006) Co-evolutionary Analysis of Domains in Interacting Proteins Reveals Insights into Domain-Domain Interactions Mediating Protein-Protein Interactions. J Mol Biol
Au et al. (2006) Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis. Acta Crystallogr D Biol Crystallogr
Yaoi et al. (2006) SH2 domain-based high-throughput assays for profiling downstream molecules in receptor tyrosine kinase pathways. Mol Cell Proteomics
Adiga et al. (2006) Development of high-throughput, polarization-maintaining, near-field probes. Appl Opt
Hashimoto et al. (2006) Arabidopsis HT1 kinase controls stomatal movements in response to CO(2). Nat Cell Biol
Braña et al. (2006) Anticancer drug discovery and pharmaceutical chemistry: a history. Clin Transl Oncol
Jennewein et al. (2006) Directed evolution of an industrial biocatalyst: 2-deoxy-D-ribose 5-phosphate aldolase. Biotechnol J
White et al. (2005) EXUBERA(R): Pharmaceutical Development of a Novel Product for Pulmonary Delivery of Insulin. Diabetes Technol Ther
Bonsor et al. (2006) Ligation independent cloning (LIC) as a rapid route to families of recombinant biocatalysts from sequenced prokaryotic genomes. Org Biomol Chem
Cheng et al. (2006) A high-throughput urinalysis of abused drugs based on a SPE-LC-MS/MS method coupled with an in-house developed post-analysis data treatment system. Forensic Sci Int
Escher et al. (2006) Passive sampling of herbicides combined with effect analysis in algae using a novel high-throughput phytotoxicity assay (Maxi-Imaging-PAM). J Environ Monit
Elias et al. (2006) Confirmation of the expression of a large set of conserved hypothetical proteins in Shewanella oneidensis MR-1. J Microbiol Methods
Berzsenyi et al. (2006) Genomics of hepatitis B and C infections: diagnostic and therapeutic applications of microarray profiling. Antivir Ther
Casimiro et al. (2006) Identification of pathogenesis-related ESTs in the crucifer downy mildew oomycete Hyaloperonospora parasitica by high-throughput differential display analysis of distinct phenotypic interactions with Brassica oleracea. J Microbiol Methods
Lehtinen et al. (2006) Real-time monitoring of antimicrobial activity with the multiparameter microplate assay. J Microbiol Methods
Pepperkok et al. (2006) High-throughput fluorescence microscopy for systems biology. Nat Rev Mol Cell Biol
Kotchoni et al. (2006) The reactive oxygen species network pathways:an essential prerequisite for perception of pathogen attack and the acquired disease resistance in plants. J Biosci
Hemby et al. (2006) Chapter 9 Assessment of genome and proteome profiles in cocaine abuse. Prog Brain Res
Büttelmann et al. (2006) Arylmethoxypyridines as novel, potent and orally active mGlu5 receptor antagonists. Bioorg Med Chem Lett
Harper et al. (2006) Methods for mining HTS data. Drug Discov Today
Heydorn et al. (2006) Protein Translocation Assays: Key Tools for Accessing New Biological Information with High-Throughput Microscopy. Methods Enzymol
Giancola et al. (2006) Utilization of the three high-throughput SNP genotyping methods, the GOOD assay, Amplifluor and TaqMan, in diploid and polyploid plants. Theor Appl Genet
Lohkamp et al. (2006) Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa. J Struct Biol

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