The Institute for Systems Biology (ISB) was co-founded by Dr. Leroy Hood, an immunologist and technologist; Dr. Alan Aderem, an immunologist; and Dr. Reudi Aebersold, a protein chemist. Since its creation in 2000, ISB has grown to hold over 170 staff members, including eleven faculty members and laboratory groups. The cutting edge technology includes facilities for DNA sequencing, genotyping, DNA arrays, and cell separations.

The Institute was developed with the intention of conducting research based on the systems biology model. This model demands the collaboration of scientists and scholars across the board, from biologists, mathematicians, and engineers, to computer scientists and physicists. At ISB these sharp minds work together in teams as they publish groundbreaking scientific papers.