TY - JOUR TI - Peroxiredoxins are conserved markers of circadian rhythms. AU - Edgar, Rachel S. AU - Green, Edward W. AU - Zhao, Yuwei AU - van Ooijen, Gerben AU - Olmedo, Maria AU - Qin, Ximing AU - Xu, Yao AU - Pan, Min AU - Valekunja, Utham K. AU - Feeney, Kevin A. AU - Maywood, Elizabeth S. AU - Hastings, Michael H. AU - Baliga, Nitin S. AU - Merrow, Martha AU - Millar, Andrew J. AU - Johnson, Carl H. AU - Kyriacou, Charalambos P. AU - O'Neill, John S. AU - Reddy, Akhilesh B. T2 - Nature AB - Cellular life emerged approximately 3.7 billion years ago. With scant exception, terrestrial organisms have evolved under predictable daily cycles owing to the Earth's rotation. The advantage conferred on organisms that anticipate such environmental cycles has driven the evolution of endogenous circadian rhythms that tune internal physiology to external conditions. The molecular phylogeny of mechanisms driving these rhythms has been difficult to dissect because identified clock genes and proteins are not conserved across the domains of life: Bacteria, Archaea and Eukaryota. Here we show that oxidation-reduction cycles of peroxiredoxin proteins constitute a universal marker for circadian rhythms in all domains of life, by characterizing their oscillations in a variety of model organisms. Furthermore, we explore the interconnectivity between these metabolic cycles and transcription-translation feedback loops of the clockwork in each system. Our results suggest an intimate co-evolution of cellular timekeeping with redox homeostatic mechanisms after the Great Oxidation Event approximately 2.5 billion years ago. DA - 2012/05/24/ PY - 2012 DO - 10.1038/nature11088 VL - 485 IS - 7399 SP - 459 EP - 464 J2 - Nature LA - eng SN - 1476-4687 0028-0836 KW - *Conserved Sequence KW - *Evolution, Molecular KW - Amino Acid Sequence KW - Animals KW - Archaea/metabolism KW - Bacteria/metabolism KW - Biomarkers/metabolism KW - Catalytic Domain KW - Circadian Clocks/genetics/physiology KW - Circadian Rhythm/genetics/*physiology KW - Eukaryotic Cells/metabolism KW - Feedback, Physiological KW - Homeostasis KW - Humans KW - Models, Biological KW - Molecular Sequence Data KW - Oxidation-Reduction KW - Peroxiredoxins/chemistry/*metabolism KW - Phylogeny KW - Prokaryotic Cells/metabolism KW - Protein Biosynthesis KW - Transcription, Genetic ER -