TY - JOUR TI - Adaptation of cells to new environments. AU - Brooks, Aaron N. AU - Turkarslan, Serdar AU - Beer, Karlyn D. AU - Lo, Fang Yin AU - Baliga, Nitin S. T2 - Wiley interdisciplinary reviews. Systems biology and medicine AB - The evolutionary success of an organism is a testament to its inherent capacity to keep pace with environmental conditions that change over short and long periods. Mechanisms underlying adaptive processes are being investigated with renewed interest and excitement. This revival is partly fueled by powerful technologies that can probe molecular phenomena at a systems scale. Such studies provide spectacular insight into the mechanisms of adaptation, including rewiring of regulatory networks via natural selection of horizontal gene transfers, gene duplication, deletion, readjustment of kinetic parameters, and myriad other genetic reorganizational events. Here, we discuss advances in prokaryotic systems biology from the perspective of evolutionary principles that have shaped regulatory networks for dynamic adaptation to environmental change. DA - 2011/10//Sep undefined PY - 2011 DO - 10.1002/wsbm.136 VL - 3 IS - 5 SP - 544 EP - 561 J2 - Wiley Interdiscip Rev Syst Biol Med LA - eng SN - 1939-005X 1939-005X KW - *Adaptation, Physiological KW - Environmental Microbiology KW - Evolution, Molecular KW - Genomics KW - Prokaryotic Cells/*physiology KW - gene regulatory networks ER -