{"id":259,"date":"2023-08-14T22:27:16","date_gmt":"2023-08-14T22:27:16","guid":{"rendered":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/?page_id=259"},"modified":"2023-09-10T14:24:09","modified_gmt":"2023-09-10T14:24:09","slug":"genome-wide-association-studies-for-allergic-diseases","status":"publish","type":"page","link":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/our-projects\/genome-wide-association-studies-for-allergic-diseases\/","title":{"rendered":"Phenome-Wide Association Studies for Allergic Diseases"},"content":{"rendered":"
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    Phenome-Wide Association Studies for Allergic Diseases<\/h1>\n\t\t\t<\/div>\n\t\t<\/div>\n\t\t
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        A Note From the Interns<\/h1>\n\t\t
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        Lea and Sarah were very grateful to have the opportunity to work with professionals in a scientific environment. The duo is excited for more research opportunities to come and are very thankful for the guidance of their mentor, the affability of their co-interns, the supportive environment at ISB, and the Amazon banana stand.<\/span><\/h4>\n<\/div>\n\t\t<\/div><\/div><\/div>
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        Project Summary<\/h1>\n\t\t
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        This summer,\u00a0Lea Repovic\u00a0and\u00a0Sarah Feng\u00a0interned with Dr. Andrew Magis in the Health Data Science Lab. They began their internship by learning about genome-wide association studies and polygenic risk scores as the foundation for their future research. After settling on allergies and allergic diseases as their topic of study, they embarked on phase one of the project: researching genes and single nucleotide polymorphisms associated with those conditions through literature mining.<\/h4>\n

        Phase two of Lea and Sarah\u2019s project was analyzing their own data with Python. Their metabolomic, proteomic, clinical, and diet data was from the Arivale database. They ran three correlation studies on this data: with single-nucleotide polymorphisms, with self-reported patient disease states, and with sex stratification. After these tests, the cohort added another layer to their research: polygenic risk scores, or an individual\u2019s genetic likelihood of having a certain disease.<\/h4>\n

        Lea and Sarah found interesting results in their analyses, which they corroborated with previously published literature. Throughout the two months, the pair honed their skills in computational biology, utilizing tools that created a more comprehensive data-driven approach to allergic diseases.<\/h4>\n<\/div>\n\t\t<\/div><\/div><\/div>
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        A Day in the Life<\/h1>\n\t\t
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        8:30<\/b> Arrive at ISB and situate ourselves at our neighboring desks. Catch up on emails, read literature relevant to the research question, use Python to test the Arivale dataset.<\/h4>\n

        10:30<\/b>\u00a0Take an excursion to the banana cart outside to boost our potassium levels, then sit outside and recharge our solar batteries.<\/h4>\n

        11:00\u00a0<\/b>Meet with our mentor, Dr. Andrew Magis, to debrief our findings and discuss next steps.<\/h4>\n

        12:00 – 1:00<\/b>\u00a0Meet up with the other interns for lunch in the Amazon courtyard or wherever we decide to eat that day.<\/h4>\n<\/div>\n\t\t<\/div><\/div>
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        1:00<\/b>\u00a0The work grind never stops.<\/h4>\n

        2:00<\/b>\u00a0Interview ISB employees about their career and life experiences.<\/h4>\n

        3:00<\/b>\u00a0High school intern-only meeting to update each other on the status of our respective projects. Plan all intern things such as interviews, the website, and fun activities outside of ISB.<\/h4>\n

        4:00 – 4:30<\/b>\u00a0Leave ISB.<\/h4>\n<\/div>\n\t\t<\/div><\/div><\/div>
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        Final Presentation<\/h1>\n\t\t
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        Lea and Sarah were very grateful to have the opportunity to work with professionals in a scientific environment. The duo is excited for more research opportunities to come and are very thankful for the guidance of their mentor, the affability of their co-interns, the supportive environment at ISB, and the Amazon banana stand.<\/p>\n","protected":false},"author":91,"featured_media":0,"parent":132,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"templates\/template-full-notitle.php","meta":{"footnotes":""},"class_list":["post-259","page","type-page","status-publish","hentry","post"],"_links":{"self":[{"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/pages\/259","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/users\/91"}],"replies":[{"embeddable":true,"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/comments?post=259"}],"version-history":[{"count":49,"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/pages\/259\/revisions"}],"predecessor-version":[{"id":1475,"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/pages\/259\/revisions\/1475"}],"up":[{"embeddable":true,"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/pages\/132"}],"wp:attachment":[{"href":"https:\/\/baliga.systemsbiology.net\/see-interns\/hs2023\/wp-json\/wp\/v2\/media?parent=259"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}