how regulatory genetic diversity drives systems-level cellular physiology
A large portion of cellular physiology and adaptation depends upon the finely tuned molecular interactions that constitute gene regulatory networks. Genetic variability of the components that participate in these interactions is highly apparent, and is likely responsible for a significant portion of the differences in biology between closely related organisms. A complete understanding of (and ability to predict) the consequences of genetically encoded regulatory variation requires a molecular model of functional change, and a means of extrapolating its effect to changes in systems-level cellular behavior. This can be accomplished by analyzing the molecular variability of regulatory elements within the context of known large-scale regulatory networks.