Fluctuating environments and extinction

Fluctuating environments and extinction

Mechanisms driving and rescuing microbial extinctions in fluctuating resource environments

There are many theories regarding why certain network topologies are necessary for generating specific environmental response dynamics, the rapidity with which regulatory networks evolve, and the impact of gene regulation on fitness. Testing the underlying hypotheses will require an integrated and coordinated systems biology approach to simultaneously infer the architecture of regulatory networks associated with relevant environmental responses of interacting organisms, analyze consequences of perturbing architecture of these networks, and track evolution of these networks during co-evolution or adaptation to a new environment

We are investigating the structure and evolution of gene regulatory networks that govern physiological responses of individual and interacting organisms in a synthetically established syntrophic pairing between a sulfate reducing bacterium, Desulfovibrio vulgaris Hildenborough (DvH) and a methanogenic archaeon Methanococcus maripaludis (Mmp).

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