|Systems approach in a multi-organism strategy to understand biomolecular interactions in DOE-relevant organisms||Hydrogen regulation and global responses to electron, carbon, and nitrogen sources in Methanococcus maripaludis|
PI: Multiple PIs
Funding: U.S. Department of Energy
ENIGMA seeks to advance the increasingly high resolution mapping from molecules to microbes and leverage the discovery of mechanisms composing the subcellular, cellular, and intercellular networks of metabolite, protein, RNA and DNA molecules that drive macroscopic biogeochemical processes, integrating these into the larger framework of interacting microbial communities and ecosystems to address DOE goals.
William B. Whitman, University of Georgia
Murray Hackett, University of Washington
Nitin Baliga, Institute for Systems Biology
Funding: US Department of Energy Office of Basic Energy Sciences, Basic Research for the Hydrogen Fuel Initiative, Award No.DE-FG02-08ER64685
1. Use transcriptomics, proteomics, and metabolomics to study the systems biology of H2 metabolism, formate metabolism, nitrogen fixation, and carbon assimilation in Methanococcus maripaludis.
2. Determine the mechanism of H2 sensing and transcriptional regulation by H2.