Maintaining homeostasis under fluctuating environmental oxygen concentrations is critical for the survival of all organisms. Extreme oxidative stress or hypoxia can overwhelm cellular redox balance, resulting in diseases such as cancer. Using a systems approach we have generated a model for the dynamic molecular information processing that occurs in response to changing oxygen concentrations. We are using this model to delineate posttranscriptional regulatory mechanisms in response to oxygen changes.
Personnel: Institute for systems Biology — Amy Schmid
Schmid AK, Reiss DJ, Kaur A, Pan M, King N, Van PT, Hohmann L, Martin DB, Baliga NS
The anatomy of microbial cell state transitions in response to oxygen.
Genome Research. 2007 Oct; 17(10): 1399-413. Epub 2007 Sep 4.
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Functional categorization of genes significantly correlated or anticorrelated with oxygen.